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Table 4 Accuracy of the Three Prognostic Tools

From: Validation of the Palliative Prognostic Index, Performance Status–Based Palliative Prognostic Index and Chinese Prognostic Scale in a home palliative care setting for patients with advanced cancer in China

 

Cutoff

Sensitivity (%, 95CI)

Specificity (%, 95CI)

PPV (%, 95CI)

NPV (%, 95CI)

OA (%, 95CI)

21 days

 PPI

4.5 a

52.0 (46.8–57.0)

79.6 (77.5–81.7)

39.9 (36.6–43.3)

86.4 (85.1–87.6)

73.9 (70.1–77.9)

5

38.2 (33.3–43.2)

89.0 (87.3–90.6)

47.6 (42.8–52.4)

84.7 (83.6–85.7)

78.5 (74.5–82.6)

6

26.2 (21.9–30.9)

92.8 (91.4–94.1)

48.8 (42.6–55.0)

82.9 (82.0–83.7)

79.0 (75.0–83.2)

 PS-PPI

6 a

52.5 (47.3–57.6)

79.4 (77.3–81.5)

40.0 (36.7–43.3)

86.5 (85.2–87.7)

73.8 (70.0–77.9)

6.5

38.4 (33.6–43.5)

87.3 (85.5–89.9)

44.0 (39.6–48.6)

84.5 (83.4–85.5)

77.2 (73.3–81.3)

7

26.2 (21.9–30.9)

90.9 (89.4–92.3)

43.0 (37.4–48.7)

82.6 (81.6–83.4)

77.5 (73.6–81.6)

 ChPS

38

67.3 (62.3–71.9)

66.9 (64.4–69.2)

34.6 (32.3–36.9)

88.7 (87.1–90.1)

67.0 (63.3–70.8)

39 a

63.9 (58.9–68.7)

70.4 (68.0–72.8)

36.0 (33.6–38.6)

88.2 (86.7–89.6)

69.1 (65.4–73.0)

40

59.2 (54.1–64.2)

74.4 (72.1–76.6)

37.6 (34.8–40.4)

87.5 (86.1–88.8)

71.3 (67.5–75.2)

42 days

 PPI

3.5

88.1 (85.6–90.3)

33.9 (31.1–36.8)

48.6 (47.4–49.9)

80.1 (76.5–83.2)

56.4 (53.1–59.9)

4 a

42.4 (38.9–46.0)

84.0 (81.7–86.2)

65.3 (61.7–68.8)

67.3 (65.8–68.7)

66.7 (63.1–70.5)

4.5

42.3 (38.8–45.9)

84.0 (81.7–86.2)

65.3 (61.6–68.8)

67.3 (65.8–68.7)

66.7 (63.1–70.5)

 PS-PPI

4

91.2 (89.0–93.1)

31.1 (28.4–34.0)

48.5 (45.9–51.1)

83.3 (79.2–86.7)

56.0 (52.7–59.5)

5

88.6 (86.2–90.8)

33.7 (30.9–36.6)

48.7 (47.4–49.9)

80.7 (77.1–83.8)

56.5 (53.1–60.0)

6 a

42.7 (39.2–46.3)

83.9 (81.5–86.0)

65.2 (61.6–68.7)

67.4 (65.9–68.8)

66.8 (63.2–70.7)

 ChPS

34

78.8 (75.7–81.6)

49.9 (46.9–52.9)

52.7 (51.0–54.5)

76.8 (74.1–79.4)

61.9 (58.4–65.6)

35 a

78.5 (75.5–81.4)

50.5 (47.4–53.5)

52.9 (51.1–54.6)

76.7 (74.0–79.2)

62.1 (58.6–65.8)

36

77.6 (74.5–80.5)

51.1 (48.1–54.1)

53.0 (51.2–54.7)

76.3 (73.6–78.8)

62.1 (58.6–65.8)

90 days

 PPI

3.5

82.5 (80.2–84.5)

38.7 (34.9–42.6)

72.1 (70.7–73.4)

53.5 (49.6–57.3)

67.5 (63.9–71.4)

4 a

34.5 (31.9–37.3)

87.6 (84.8–90.1)

84.3 (81.1–87.0)

41.1 (39.9–42.3)

52.7 (49.5–56.1)

4.5

34.5 (31.8–37.2)

87.6 (84.8–90.1)

84.2 (81.1–86.9)

41.0 (39.8–42.3)

52.7 (49.5–56.1)

 PS-PPI

4

85.6 (83.5–87.5)

36.1 (32.3–39.9)

72.0 (70.7–73.2)

56.5 (52.3–60.7)

68.6 (64.9–72.5)

4.5 a

85.1 (82.9–87.0)

37.8 (34.0–41.7)

72.4 (71.1–73.7)

56.8 (52.7–60.9)

68.9 (65.2–72.8)

5

83.0 (80.8–85.1)

38.7 (34.9–42.6)

72.2 (70.9–73.5)

54.3 (50.4–58.2)

67.8 (64.2–71.7)

 ChPS

28

86.1 (84.1–88.0)

34.0 (30.3–37.8)

71.5 (70.2–72.7)

56.1 (51.7–60.4)

68.3 (64.6–72.1)

33

71.4 (68.8–73.9)

54.6 (50.6–58.5)

75.1 (73.3–76.8)

49.9 (47.0–52.7)

65.6 (62.0–69.4)

38 a

49.1 (46.3–52.0)

77.0 (73.5–80.2)

80.4 (77.9–82.7)

44.1 (42.4–45.8)

58.7 (55.2–62.3)

  1. Abbreviations: CI confidence intervals, PPV Positive Predictive Value, NPV Negative Predictive Value, OA Overall Accuracy, PPI Palliative Prognostic Index, PS-PPI Performance Status-Based Palliative Prognostic Index; ChPS Chinese Prognostic Scale. a Data were expressed as the best cutoff score based on Youden index (Youden index = sensitivity+ specificity- 1)