Table 2 Univariate and multivariate Cox regression analysis of factors associated with OS for the main training cohort

Significant factors

 Age ≥ 60 years (vs. < 60 years)

1.383 (1.023–1.871)

1.215 (0.885–1.669)

 KPS < 70 (vs. ≥ 70)

2.046 (1.501–2.789)

0.750 (0.524–1.074)

 Stage IV (vs. IIIB)

1.784 (1.131–2.814)

1.794 (1.124–2.863)

 Loss of appetite

2.123 (1.586–2.842)

1.192 (0.861–1.651)

 Cancer pain

1.929 (1.268–2.932)

1.354 (0.869–2.108)

 Treatment method, supportive care (vs. others)

5.551 (3.939–7.709)

3.457 (2.383–5.016)

 NLR, > 6.8 (vs. ≤ 6.8)

2.619 (1.922–3.569)

1.082 (0.713–1.642)

 NAR, > 0.15 (vs. ≤ 0.15)

2.831 (2.102–3.813)

1.674 (1.108–2.527)

 PG-SGA score, > 12 (vs. ≤ 12)

3.348 (2.481–4.519)

2.396 (1.665–3.446)

Nonsignificant factors

 Sex, female (vs. male)

1.299 (0.931–1.813)

 Histology, small-cell lung cancer (vs. other)

1.329 (0.903–1.956)

 Diarrhoea

1.625 (0.902–2.928)

 Nausea

1.015 (0.700–1.472)

 Vomiting

1.223 (0.823–1.818)