| Starting doses – Day 0 | Day 7 | Day 14 | Day 28 | |
---|---|---|---|---|---|
 | Mirtazapine: 15 mg Escitalopram: 10 mg (or 5 mg for patients older than 65) |  |  |  | |
Excessive drowsiness (CTCAE grade 1 or rated moderate or severe using the ASEC) | Â | For patients under 65 in the escitalopram arm: decrease to 5Â mg | Â | Â | |
For every other patients: Stop the treatment | |||||
Any severe adverse effect or serious adverse event (CTCAE grade > 3 or rated severe using the l’ASEC) |  | Stop the treatment | |||
Moderate adverse event (CTCAE grade 2 or rated moderate using the ASEC) | Â | Decrease the dosage (Or treatment stop if already at the lower dosage) | |||
Mild adverse event (CTCAE grade 1 or rated mild using the ASEC) | Â | No dose adjustment | |||
No adverse event | Inadequate symptoms’ control (ESAS > 3) |  | No dose adjustment (or increase the dosage if escitalopram has been started at 5 mg) | Increase the dosage | |
Adequate symptoms’ control (ESAS ≤ 3) |  | No dose adjustment |