Quality of life and depression in patients with amyotrophic lateral sclerosis – does the country of origin matter?

Ciećwierska, Katarzyna; Lulé, Dorothée; Bielecki, Maksymilian; Helczyk, Olga; Maksymowicz-Śliwińska, Anna; Finsel, Julia; Nieporęcki, Krzysztof; Andersen, Peter M.; Ludolph, Albert C.; Kuźma-Kozakiewicz, Magdalena

doi:10.1186/s12904-023-01189-2

Table 4 Regression coefficients obtained in multiple regression models predicting ACSA, SEIQoL-DW and ADI results in ALS patients

From: Quality of life and depression in patients with amyotrophic lateral sclerosis – does the country of origin matter?

	ACSA		SEIQoL-DW		ADI-12
Term	b	95% CI	b	95% CI	b	95% CI
(Intercept)	-0.19	[-0.57, 0.18]	70.54**	[67.90, 73.17]	23.88**	[23.08, 24.69]
Country 1	0.05	[-0.57, 0.67]	5.27*	[0.87, 9.67]	-2.28**	[-3.61, -0.94]
Country 2	0.06	[-0.38, 0.51]	43,891	[-2.07, 4.14]	0.56	[-0.40, 1.53]
Age	0.01	[-0.02, 0.04]	0.03	[-0.20, 0.26]	0.07	[-0.00, 0.14]
Gender	0.19	[-0.15, 0.52]	15,342	[-0.93, 3.76]	-0.64	[-1.36, 0.08]
ALSFRS-R	0.05*	[0.01, 0.09]	0.19	[-0.12, 0.49]	-0.20**	[-0.29, -0.11]
Disease duration	0.02	[-0.00, 0.04]	0.05	[-0.11, 0.20]	-0.07**	[-0.12, -0.02]
*Country 1 Age**	0.01	[-0.05, 0.06]	0.01	[-0.39, 0.41]	0.06	[-0.06, 0.18]
*Country 2 Age**	-0.02	[-0.06, 0.02]	0.17	[-0.12, 0.46]	-0.03	[-0.12, 0.06]
*Country 1 Gender**	-0.15	[-0.71, 0.40]	22,706	[-0.26, 7.51]	0.81	[-0.39, 2.01]
*Country 2 Gender**	-0.24	[-0.67, 0.19]	-1.99	[-5.02, 1.04]	-0.25	[-1.18, 0.69]
*Country 1 ALSFRS-R**	-0.04	[-0.10, 0.02]	-0.20	[-0.67, 0.27]	0.05	[-0.09, 0.18]
*Country 2 ALSFRS-R**	0.09**	[0.04, 0.14]	0.45*	[0.06, 0.83]	-0.16**	[-0.27, -0.04]
*Country 1 Disease duration**	0.01	[-0.02, 0.04]	-0.09	[-0.31, 0.14]	-0.01	[-0.08, 0.06]
*Country 2 Disease duration**	0.00	[-0.03, 0.04]	-0.04	[-0.26, 0.18]	-0.01	[-0.08, 0.06]
*Age Gender**	0.00	[-0.02, 0.03]	0.08	[-0.12, 0.28]	-0.06	[-0.12, 0.01]
*Age ALSFRS-R**	0.00	[-0.00, 0.01]	0.00	[-0.02, 0.03]	-0.00	[-0.01, 0.01]
*Age Disease duration**	0.00	[-0.00, 0.00]	0.00	[-0.02, 0.02]	-0.00	[-0.01, 0.00]
*Gender ALSFRS-R**	0.00	[-0.04, 0.04]	0.21	[-0.08, 0.51]	-0.06	[-0.15, 0.02]
*Gender Disease duration**	-0.02*	[-0.04, -0.00]	-0.03	[-0.18, 0.13]	0.00	[-0.05, 0.05]
*ALSFRS Disease duration**	0.00	[-0.00, 0.00]	-0.01	[-0.03, 0.01]	0.00	[-0.00, 0.01]

Note: Disease duration: time since disease onset (in months); ALSFRS-R: amyotrophic lateral sclerosis functional rating scale-revised; ACSA: anamnestic comparative self-assessment; SEIQoL-DW: Schedule for the evaluation of the subjective quality of life - SEIQoL- direct weighting; ADI-12: ALS-Depression-Inventory 12 Items. Countries are represented using contrasts codes: Country 1 (SE - PL), Country 2 (DE - PL). Contrast coding for Gender: Females = 1, Males = -1. All continuous predictors are mean-centered
* indicates p < 0.05; ** indicates p < 0.01

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